Pharmaceutical compositions containing as active substance sulphur-containing carboxylic acids and their use in combating retroviruses
AssigneeAsta Pharma Aktiengesellschaft
InventorsJoachim Kalden, Bernhard Fleckenstein, Andreas Baur, Thomas Harrer
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Abstract
Pharmaceutical compositions containing at least one compound of Formula I, ##STR1## where X is a hydrogen atom or both X's represent a direct link between the two sulphur atoms; Y is hydrogen or C.sub.1 -C.sub.6 alkyl and n represents a number from 1 to 10, or their pharmaceutically acceptable salts including .alpha.-lipoic acid and dihydrolipoic acid. The pharmaceutical compositions are useful for the treatment of diseases caused by retroviruses.
Claims22
A dosage unit of a pharmaceutical composition containing at least one compound of Formula I, ##STR4## where X is a hydrogen atom and both X's represent a direct link between the two sulphur atoms;
- Y is hydrogen or a C.sub.1 -C.sub.6 -alkyl and n represents a number from 1 to 10 with the exception to .alpha.-lipoic acid and dihydrolipoic acid, or a pharmaceutically acceptable salt of said compound of Formula I
- the dosage unit being a solid or semi-solid formulation containing 20 mg to 6 g of the total amount of active ingredient of Formula I, or the dosage nit being a solution, suspension or emulsion which contains 0.2 mg to 800 mg per ml, of the total amount of active ingredient of Formula I.
A dosage unit of a pharmaceutical composition containing .alpha.-lipoic acid, the dosage unit being a solid or semi-solid formulation containing 51 mg to 6 g .alpha.-lipoic acid or a pharmaceutically acceptable salt thereof or an injection solution which contains 26 mg to 500 mg per ml .alpha.-lipoic acid or a pharmaceutically acceptable salt thereof, or a drinkable solution, suspension or emulsion which contains 1 mg to 500 mg per ml of .alpha.-lipoic acid or a pharmaceutically acceptable salt thereof.
A dosage unit of a pharmaceutical composition containing dihydrolipoic acid in which the dosage unit is a solid or semi-solid formulations which contains 601 mg to 6 g dihydrolipoic acid or a pharmaceutically acceptable salt thereof, or a solution, suspension or emulsion which contains 182 mg/ml to 1137 mg/ml dihydrolipoic acid or a pharmaceutically acceptable salt thereof.
A method of treating a disorder caused by a retrovirus which comprises administering an effective amount of a pharmaceutical composition which contains a compound of Formula I, ##STR5##
Dependencies are inferred from the claim text.