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US 5,334,602 AGranted
Aryloxalkylamine derivatives and uses thereof
AssigneeLaevosan-Gesellschaft GmbH
InventorsBernhard Lotz, Gerhard Greier
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AssigneeLaevosan-Gesellschaft GmbH
InventorsBernhard Lotz, Gerhard Greier
Estimating the term…
New aryloxy-alkylamine derivatives of the general formula I ##STR1## in which A signifies a benzene or thiophene ring, R and R.sub.1, independently of one another, each hydrogen, alkyl, halogen, CF.sub.3 or alkoxy, R.sub.2 alkyl, cycloalkyl, alkenyl, alkynyl, alkaryl or saturated or unsaturated aliphatic or aromatic acyl, R.sub.3 and R.sub.4 in each case hydrogen, alkyl, alkenyl, alkynyl or cycloalkyl with, in each case, up to 8 C-atoms, whereby R.sub.3 and R.sub.4 can be the same or different but are not simultaneously hydrogen or R.sub.3 and R.sub.4, together with the nitrogen atom connecting them, form a 5- to 7-membered saturated ring or a saturated heterocyclic ring which can possibly contain an oxygen or nitrogen atom as a further heteroatom in the ring, whereby an additional nitrogen atom can be substituted by an alkyl radical with up to 3 C-atoms, and their acid-addition salts possess interesting pharmaceutical properties and are especially suitable as anti-arrhythmics.
A compound of formula ##STR6## wherein A is a benzene or thiophene ring, R and R.sub.1 are each hydrogen, alkyl of 1 to 8 carbon atoms, halogen, CF.sub.3 or alkoxy of 1 to 8 carbon atoms, R.sub.2 is alkyl of 1 to 8 carbon atoms, cycloalkyl of 1 to 8 carbon atoms, alkynyl of 1 to 8 carbon atoms, or alkaryl of 1 to 8 carbon atoms, R.sub.3 and R.sub.4 are each hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl of 1 to 8 carbon atoms, alkynyl of 1 to 8 carbon atoms or cycloalkyl of 1 to 8 carbon atoms, whereby R.sub.3 and R.sub.4 are the same or different but are not both hydrogen, or R.sub.3 and R.sub.4, together with the nitrogen atom connecting them, form a 5 to 7-membered saturated ring or a saturated heterocyclic ring optionally containing an oxygen or nitrogen atom wherein said optional nitrogen atom is optionally substituted by an alkyl of 1 to 3 carbon atoms, acid addition salts thereof and optically active isomers thereof.
1-[3-(2-Methoxy-3-(2-methylpropylamino)-propoxy)-4-methyl-2-th ienyl]-3-phenyl-1-propanone.
1-[3-(2-Methoxy-3-(2-meth ylpropylamino)-propoxy)-4-methyl-2-thienyl]3-phenyl-1-propanone hydrochloride.
2-(2-Methoxy-3-propylaminopropoxy)-3-phenylpropiophenone.
2-(2-Methoxy-3-propylaminopropoxy)-3-phenylpropiophenone hydrochloride.
Compound selected from the group consisting of:
Compound selected from the group consisting of:
Process for preparing a compound of formula:
Dependencies are inferred from the claim text.