Pyrazoloquinolones as anticancer agents

A compound of formula ##STR9## wherein R.sub.1 is hydrogen, lower-alkyl, or trifluoromethyl;

• R.sub.2 is lower-alkyl, trifluoromethyl or CH.sub.2 Y where Y is hydroxy, chloro, lower-alkylamino or dilower-alkylamino
• R.sub.3 and R.sub.4 are each independently hydrogen or fluoro;
• R.sub.5 is hydrogen, lower-alkyl or
• (a) phenyl, 2-pyridyl, 4-pyridyl, 1-naphthyl or such groups substituted with one to about three, the same or different, lower-alkyl, fluoro, hydroxy, or lower-alkoxy;
• (b) C.sub.4 to C.sub.7 cycloalkyl or C.sub.4 to C.sub.7 cycloalkyl substituted with amino, lower-alkylamino, dilower-alkylamino, formamido, acetamido, lower-alkyl, hydroxy, lower-alkoxy, trifluoromethyl, carboxy, lower-alkoxycarbonyl or halo, or C.sub.4 to C.sub.7 cycloalkyl having a phenyl ring fused thereto, forming a C.sub.8 to C.sub.11 bicyclic radical wherein 1 ring is aromatic and the other saturated;
• (c) A saturated carbon containing heterocyclic 5- or 6-membered ring containing oxygen and/or nitrogen or such ring substituted with lower-alkyl where if both nitrogen and oxygen are present they are non-adjacent;
• or
• (d) (CH.sub.2).sub.n -Z wherein n is an integer from one to four and Z is amino, dilower-alkylamino, bis(hydroxylower-alkyl) lower-alkylamino, hydroxy, trifluoromethyl, carboxy, lower-alkoxycarbonyl, lower-alkoxy, formyl or acetal thereof, or a substituent selected from (a), (b) or (c);
• or a pharmaceutically acceptable acid addition salt thereof.