Amphoteric tricyclic compound
AssigneeHokoriku Pharmaceutical Co., Ltd.
InventorsYasuo Ito, Hideo Kato, Shingo Yasuda, Noriyuki Kado, Nobuhiko Iwasaki, Hiroyuki Nishino, Makoto Takeshita
Life of this patent
Estimating the term…
Abstract
Novel amphoteric tricyclic compound represented by the following formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a halogen atom; X represents --O--, --CH.sub.2 O--, or --OCH.sub.2 --; and Y represents a C.sub.2 -C.sub.5 alkylene group which may optionally be substituted with a lower alkyl group, and a pharmacologically acceptable salt thereof are disclosed. Also disclosed are a pharmaceutical composition comprising the same and a method for treatment of an allergic disease or bronchial asthma.
Claims9
An amphoteric tricyclic compound represented by the following formula:
- ##STR11## wherein R.sup.1 represents a hydrogen atom or a halogen atom;
- X represents --O--, --CH.sub.2 O--, or --OCH.sub.2 --;
- and Y represents a C.sub.2 -C.sub.5 alkylene group which may optionally be substituted with a lower alkyl group, and a pharmacologically acceptable salt thereof.
3-[4-(8-Fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11- ylidene)piperidino]propionic acid and a pharmacologically acceptable salt thereof.
3-[4-( 8-Chloro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]pro pionic acid and a pharmacologically acceptable salt thereof.
A pharmaceutical composition comprising an effective amount of an amphoteric tricyclic compound represented-by the following formula:
- ##STR12## wherein R.sup.1 represents a hydrogen atom or a halogen atom;
- X represents --O--, --CH.sub.2 O--, or --OCH.sub.2 --;
- and Y represents a C.sub.2 -C.sub.5 alkylene group which may optionally be substituted with a lower alkyl group, or a pharmacologically acceptable salt thereof together with a pharmaceutically acceptable carrier or coating.
A method for the treatment of an allergic disease comprising the step of administering to a mammal an effective amount of an amphoteric tricyclic compound represented by the following formula:
- ##STR13## wherein R.sup.1 represents a hydrogen atom or a halogen atom;
- X represents --O--, --CH.sub.2 O--, or --OCH.sub.2 --;
- and Y represents a C.sub.2 -C.sub.5 alkylene group which may optionally be substituted with a lower alkyl group, or a pharmacologically acceptable salt thereof.
A method for the treatment of bronchial asthma comprising the step of administering to a mammal an effective amount of an amphoteric tricyclic compound represented by the following formula:
- ##STR14## wherein R.sup.1 represents a hydrogen atom or a halogen atom;
- X represents --O--, --CH.sub.2 O--, or --OCH.sub.2 --;
- and Y represents a C.sub.2 -C.sub.5 alkylene group which may optionally be substituted with a lower alkyl group, or a pharmacologically acceptable salt thereof.
Dependencies are inferred from the claim text.