Certain PAF antagonist antihistamine combinations and methods
AssigneeSchering Corporation
InventorM. Motasim Billah
Life of this patent
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Abstract
Methods and compositions are disclosed employing combinations of antihistamines with certain diaryl tetrahydrofuran, diaryl tetrahydrothiophene, triazolobenzodiazepine or thienotriazolodiazepine PAF-antagonist compounds in the treatment of allergic reactions.
Claims9
A method for treating allergic reactions in a mammal comprising administering an anti-allergic effective amount of a combination comprising a PAF-antagonist and an antihistamine, said PAF-antagonist being selected from 4-(2-chlorophenyl)-9-methyl-6H-thieno [3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine-2-propionic acid morpholide and 2,5-bis(3,4,5-trimethoxyphenyl)tetrahydrofuran, and said antihistamine being selected from chlorpheniramine, clemastine, and ketotifen.
A pharmaceutical composition suitable for treating allergic reactions comprising an anti-allergic effective amount of a PAF-antagonist in combination with an antihistamine, said PAF-antagonist selected from 4-(2-chlorophenyl)-9-methyl-6H-thieno [3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepiine-2-propionic acid morpholide and 2,5-bis(3,4,5-trimethoxyphenyl) tetrahydrofuran, and said antihistamine is selected from chlorpheniramine, clemastine;
- and ketotifen.
Dependencies are inferred from the claim text.