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US 5,334,590 AGranted
MRSA active 2-phenyl-carbapenems
AssigneeMerck & Co., Inc.
InventorsFrank DiNinno, Ravindra N. Guthikonda
Life of this patent
Estimating the term…
Abstract
Carbapenems of the formula ##STR1## are useful antibacterial agents.
Claims12
A compound of the formula:
- ##STR88## wherein:
- R is H or CH.sub.3 ;
- R.sup.2 is (R)--CH.sub.3 CH(OH)-- or (R)--CH.sub.3 CH(F)--;
- R.sup.a1 is halogen, --SCH.sub.3, --S(O).sub.2 CH.sub.3 and --(C.dbd.O)H;
- R.sup.a3 is halogen, --SCH.sub.3, --S(O).sub.2 CH.sub.3, --(C.dbd.O)H, --(S.fwdarw.O)CH.sub.3 and --cyano;
- and
- M is a pharmaceutically acceptable cation or ester.
4 more elements
A compound of the formula:
- ##STR89## wherein R.sup.a1 and R.sup.a3 are simultaneously selected from the pairs of the group consisting of:
- ______________________________________ R.sup.a1 Ra3 ______________________________________ F F Cl Cl Br Br Br Cl I I I Br I Cl Br HC.dbd.O I HC.dbd.O Br SMe Br (S.fwdarw.O)Me Br S(O).sub.2 Me I SMe I (S.fwdarw.O)Me I S(O).sub.2 Me SMe SMe SMe (S.fwdarw.O)Me (S.fwdarw.O)Me S(O).sub.2 Me S(O).sub.2 Me S(O).sub.2 Me SMe HC.dbd.O (S.fwdarw.O)Me HC.dbd.O S(O).sub.2 Me HC.dbd.O I CN HC.dbd.O CN (S.fwdarw.O)Me CN and S(O).sub.2 Me CN. ______________________________________
A compound of the formula I:
- ##STR90## or a pharmaceutically acceptable salt or solvate thereof, wherein:
- R is hydrogen or methyl;
- R.sup.2 is (R)CH.sub.3 CH(OH)-- or (R)CH.sub.3 CH(F)--;
- R.sup.a1 and R.sup.a3 are independently Cl, Br, F, I, --SCH.sub.3, --CH.sub.2 OH, --S(O)CH.sub.3, --SO.sub.2 CH.sub.3 or --CHO;
- and
- M is a cation or an ester forming group.
3 more elements
Dependencies are inferred from the claim text.