Composition for inhibiting transmission of hepatitis B virus
AssigneeThe Trustees of Columbia University in the City of New York
InventorsCharles L. Fox, Jr., deceased, Shanta M. Modak
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Abstract
The present invention relates to methods of inhibiting transmission of Hepatitis B virus using compositions comprising silver sulfadiazine and preferably further comprising a biguanide such as chlorhexidine and/or a detergent such as sodium deoxycholate. It is based, at least in part, on the discovery that silver sulfadiazine alone or in combination with chlorhexidine or sodium deoxycholate was shown to inhibit Hepatitis B virus DNA synthesis. The inhibitory effect of silver sulfadiazine was enhanced by combining silver sulfadiazine with either chlorhexidine or sodium deoxycholate.
Claims9
A method for inhibiting transmission of hepatitis B virus, comprising applying to a patient a composition comprising an effective antiviral amount of silver sulfadiazine at a site where contact with hepatitis B virus may occur.
Dependencies are inferred from the claim text.