Pharmaceutical bacteriocin compositions and methods for using the same
AssigneeApplied Microbiology, Inc.
InventorsPeter Blackburn, Steven J. Projan, Edward B. Goldberg
Life of this patent
Estimating the term…
Abstract
Compositions comprising lanthionine-containing bacteriocins such as nisin in combination with a chelator act as bactericides in low pH environments. In a preferred embodiment pharmaceutical preparations containing the compositions are used for the control of bacteria responsible for disorders of the gastrointestinal tract.
Claims26
A method of preventing or treating for bacterial infection in a low-pH environment in the range of pH 2-5 comprising contacting the bacteria with a composition comprising a lanthionine-containing bacteriocin and a chelating agent in a pharmaceutically acceptable carrier.
A method of preventing or treating a bacterial infection in the gastrointestinal tract comprising administering into the gastrointestinal tract a composition comprising a lanthionine-containing bacteriocin and a chelating agent.
A method of treating gastrointestinal disorders in mammals due to the presence of Escherichia coli bacteria comprising contacting the bacteria with a composition comprising nisin and a chelating agent in a pharmaceutically acceptable carrier.
A method of treating gastrointestinal disorders in mammals due to the presence of Helicobacter pylori bacteria comprising contacting the bacteria with a composition comprising nisin and a chelating agent in a pharmaceutically acceptable carrier.
A method of treating gastrointestinal disorders in mammals due to the presence of Salmonella bacteria comprising contacting the bacteria with a composition comprising nisin and a chelating agent in a pharmaceutically acceptable carrier.
A pharmaceutical composition useful for treating gastrointestinal disorders due to gram negative bacteria comprising a suitable amount of nisin, a chelating agent, an acid vehicle, and a pharmaceutically acceptable carrier.
A pharmaceutical composition useful for treating gastrointestinal disorders due to microorganisms comprising an effective amount of a lanthionine-containing bacteriocin, a chelator, an acid vehicle and a pharmaceutically acceptable carrier.
A method for inhibiting the growth of or killing bacteria in a low-pH environment in the range of pH 2-5 comprising contacting the bacteria with a composition comprising a lanthionine-containing bacteriocin and a chelating agent in a suitable carrier.
Dependencies are inferred from the claim text.