Microbial process for the production of trans-4-hydroxy-L-proline
AssigneeSankyo Company, Limited
InventorsTatsuji Matsuoka, Nobufusa Serizawa, Tsuyoshi Hosoya, Kouhei Furuya
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Abstract
Trans-4-hydroxy-L-proline is produced microbially, especially by the cultivation of a microorganism of the genus Clonostachys, Gliocladium or Nectria.
Claims19
A process for the preparation of trans-4-hydroxy-L-proline comprising cultivating in a culture broth a trans-4-hydroxy-L-proline producing microorganism, said microorganism being a species of a genus selected from the group consisting of Clonostachys, Gliocladium and Nectria, and separating the resulting trans-hydroxy-L-proline from the culture broth.
A process for the preparation of trans-4-hydroxy-L-proline comprising cultivating in a culture broth a trans-4-hydroxy-L-proline producing microorganism of the genus Clonostachys, of the genus Gliocladium or of the genus Nectria at a pH of 5.0 to 7.0 and at a temperature of 15.degree. to 28.degree. C., and separating the resulting trans-4-hydroxy-L-proline from the culture broth.
Dependencies are inferred from the claim text.