# US 5,334,511 A · Isolated mink growth hormone genes, novel recombinant DNA and methods for producing mink growth hormone

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- Number: US 5,334,511 A
- Document ID: US5334511A
- Status: Granted
- Kind: A
- Application number: 07/963,331
- Filed: 1992-10-16
- Granted: 1994-08-02
- Earliest claimed: 1992-10-16
- Assignees: Kikkoman Corporation
- Inventors: Yasuhiro Harada; Eiichi Nakano; Hiroki Tatsumi; Motoaki Umezu
- Web page: https://patentgrep.com/patent/US5334511A

## CPC

- C07K 14/61: Growth hormone [GH], i.e. somatotropin
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides an improved mink growth hormone gene, a recombinant DNA containing the improved mink growth hormone gene, microorganisms which belong to the genus Escherichia and contain the recombinant DNA and which are capable of producing a mink growth hormone, and a method for producing a mink growth hormone using the E.coli transformant containing the recombinant DNA. According to the present invention, a mink growth hormone is efficiently produced.

## Claims

### Claim 1

An isolated mink growth hormone gene defined in SEQ ID No. 1.

### Claim 2 (depends on 1)

A recombinant DNA comprising a vector DNA into which the isolated mink growth hormone gene of claim 1 is inserted.

### Claim 3 (depends on 2)

A method for producing a mink growth hormone comprising, culturing in a culture medium microorganisms which belong to the genus Escherichia and which contain the recombinant DNA of claim 2 and which are capable of producing a mink growth hormone, and recovering the mink growth hormone from the culture.