Cytokine and hormone carriers for conjugate vaccines
AssigneeAmerican Cyanamid Company
InventorsSubramonia Pillai, Ronald Eby
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Abstract
This invention pertains to immunogenic conjugates comprising a carbohydrate containing antigen or other antigen bound to or genetically fused with a cytokine, lymphokine, hormone or growth factor having immunomodulating activity, wherein the cytokine, lymphokine, hormone or growth factor is capable of modifying immunogenicity of the carbohydrate containing antigen. The cytokine or lymphokine can be an interleukin or an interferon. The immunogenic conjugate can be used in vaccine and co-vaccine formulations.
Claims17
An immunogenic conjugate comprising a bacterial capsular polymer bound to a lymphokine selected from the group consisting of interferon, interleukin 1.alpha., interleukin-2.beta. and interleukin-2.
A vaccine composition, comprising an immunogenic conjugate, comprising a bacterial capsular polymer bound to a lymphokine selected from the group consisting of interferon, interleukin-1.alpha., interleukin-1.beta. and interleukin-2, in a pharmaceutically acceptable vehicle and an optional adjuvant.
An immunogenic conjugate comprising polyribosylribitolphosphate bound to interleukin-2, wherein interleukin-2 is capable of modifying the immunogenic activity of polyribosylribitolphosphate.
A vaccine composition comprising an immunogenic conjugate comprising polyribosylribitolphosphate bound to interleukin-2, wherein interleukin-2 is capable of modifying the immunogenic activity of polyribosylribitolphosphate, in a pharmaceutically acceptable vehicle and an optional adjuvant.
Dependencies are inferred from the claim text.