Pharmaceutical formulation in the form of aqueous suspension
AssigneeRohto Pharmaceutical Co., Ltd.
InventorsYouko Mitani, Kenji Muta, Mitsuo Umemoto
Life of this patent
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Abstract
A pharmaceutical formulation in the form of aqueous suspension which comprises an ion exchange resin carrying an active ingredient and a suspending agent, characterized in that the formulation further contains a basic or neutral amino acid or a salt thereof as a dispersion stabilizer.
Claims10
A pharmaceutical formulation in the form of an aqueous suspension capable of maintaining a uniform dispersion upon storage which comprises (a) 0.01-3.00 w/v % of an ion exchange resin carrying an active ingredient capable of being converted into an ionic active ingredient, (b) 0.10-3.00 w/v % of a suspending agent selected from the group consisting of natural gums, nonionic cellulose derivatives and alginates and mixtures thereof, (c) 0.05-2.00 w/v % of a dispersion stabilizer comprising an amino acid selected from the group consisting of glycine, alanine, cystine, valine, lysine, arginine, histidine and salts thereof and (d) 92.00-99.84 w/v % of water, wherein said maintained uniform dispersion is the effect of the amino acid dispersion stabilizer on the ion exchange resin carrying an active ingredient and the suspending agent.
Dependencies are inferred from the claim text.