Pharmaceutical compositions containing pentamidine
AssigneeFisons Limited
InventorsPhilip S. Hartley, John Stevens
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Abstract
Pharmaceutical compositions suitable for administration by inhalation and containing pentamidine, or pharmaceutically acceptable salt thereof, in powder form. Such compositions include pressurized aerosol compositions and nonpressurized power compositions. Also described is finely divided powdered pentamidine with a mass median diameter in the range 0.01 to 10 microns and a method for the prevention or treatment of pneumo-cystis carinii pneumonia which comprises administration by inhalation to a patient having or susceptible to that condition of a therapeutically effective quantity of pentamidine, or a pharmaceutically acceptable salt thereof, in powder form.
Claims3
A pressurized powder pharmaceutical composition for the prophylactic or remedial treatment of pneumo-cystis carinii pneumonia by oral or nasal inhalation, said composition containing as active ingredient, from 0.5 to 12% by weight of dry, finely divided particulate pentamidine or a pharmaceutically acceptable salt thereof with a mass median diameter of from 0.01 to 10 microns, and a pharmaceutically acceptable liquefied gas aerosol propellant, said finely divided pentamidine or salt thereof being dispensed in a stream of said liquefied gas propellant which vaporizes, providing an aerosol of dry powder.
Dependencies are inferred from the claim text.