Platelet receptor antagonists useful in detecting intravascular platelet aggregation
AssigneeMedical University of South Carolina
InventorsPerry V. Halushka, Ken M. Spicer, Dale E. Mais
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Abstract
This invention provides novel compounds used in a method of determining platelet deposition. These compounds include .sup.123 I-SAP and analogues. Also provided is a method of determining platelet deposition in a subject comprising binding an effective radiolabeled platelet receptor antagonist with a platelet, allowing sufficient time for the platelet to migrate within the subject, and visualizing the radiolabeled platelet in the subject.
Claims10
A method of determining platelet deposition in a subject comprising binding an effective radiolabeled thromboxane A.sub.2 receptor antagonist with a platelet, allowing sufficient time for the platelet to migrate within the subject, and visualizing the radiolabeled platelet in the subject.
A method of diagnosing a disorder associated with platelet deposition comprising binding an effective radiolabeled thromboxane A.sub.2 receptor antagonist with a platelet, allowing sufficient time for the platelet to migrate within the subject, and visualizing the radiolabeled platelet in the subject, the presence of intravascular artery platelet deposition indicating the presence of the disorder.
Dependencies are inferred from the claim text.