Column with macroporous polymer media
AssigneeCornell Research Foundation, Inc.
InventorsJean M. J. Frechet, Frantisek Svec
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Abstract
A continuous liquid chromatographic column containing a separation medium in the form of a macroporous polymer plug is disclosed. The column possesses numerous advantages over conventional columns which are packed with beads or particles. The plug contains both small pores less than 200 nm in diameter and large pores greater than 600 nm in diameter.
Claims16
A continuous liquid chromatographic column comprising a rigid tube and at least one continuous plug of a macroporous organic polymer disposed within the column and extending across the cross-sectional area of the column, wherein the plug contains small pores having diameters less than about 200 nm and large pores having diameters greater than about 600 nm.
A column comprising a rigid tube and at least one continuous plug of a macroporous organic polymer disposed within the column and extending across the cross-sectional area of the column, wherein the plug contains small pores having diameters less than about 200 nm and large pores having diameters greater than about 600 nm and wherein said column is capable of passing a liquid selected from an organic solvent and water therethrough at a linear flow rate of at least about 200 cm/hr and at a pressure of less than about 30 MPa (4,500 psi).
Dependencies are inferred from the claim text.