Method and composition for increased skin concentration of active agents by iontophoresis
AssigneesNorth Carolina State University, Becton, Dickinson and Company
InventorsBurton H. Sage, Jr., Jim E. Riviere
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Abstract
The invention discloses methods and compositions for enhanced skin concentration of iontophoretic delivered active agents. The compositions are pharmaceutically acceptable compositions for iontophoretic delivery which comprise a skin concentration enhancing amount of a vasoconstrictor and active agent. Methods comprise adding a skin concentration enhancing amount of a vasoconstrictor to an active agent and delivering by iontophoresis.
Claims14
A method for enhancing skin concentration of iontophoretic delivered active agents comprising:
- (a) adding to an active agent an imidazoline vasoconstrictor in an amount effective to enhance the skin concentration of the active agent when delivered iontophoretically;
- and
- (b) delivering a pharmaceutically acceptable composition of said active agent and vasoconstrictor by iontophoresis.
A method for enhancing skin concentration of iontophoretic delivered active agents comprising:
- (a) adding to an active agent a vasoconstrictor in an amount effective to enhance the skin concentration of the active agent when delivered iontophoretically;
- and
- (b) delivering a pharmaceutically acceptable composition of said active agent and vasoconstrictor by iontophoresis, wherein said vasoconstrictor is an imidazoline selected from the group consisting of naphazoline, oxymetazoline, tetrahydrozaline, fenoxazoline, indanazoline, tramazoline, tymazoline, and xylometazoline.
Dependencies are inferred from the claim text.