Processes for producing 5-fluorobenzoic acids and their intermediates
AssigneesAsahi Glass Company, Limited, Seimi Chemical Co., Ltd.
InventorsSeisaku Kumai, Masao Ohashi, Yutaka Yaginuma, Katsuhiko Takeda
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Abstract
A process for producing a 5-fluorobenzoic acid of the formula (V), which comprises trichloromethylating a fluorobenzene of the formula (I) to obtain a 5-fluorobenzotrichloride of the formula (II), then reacting it with aqueous ammonia to obtain a 5-fluorobenzonitrile of the formula (III), reacting it with a fluorinating agent to obtain a 5-fluorobenzonitrile of the formula (IV) and hydrolyzing it: ##STR1## wherein each of X.sub.1, X.sub.3, Y.sub.1 and Y.sub.3 is a halogen atom, and each of X.sub.2 and Y.sub.2 is hydrogen or a halogen atom.
Claims4
A process for producing a 5-fluorobenzonitrile, which comprises trichloromethylating a fluorobenzene of the formula (I) to obtain a 5-fluorobenzotrichloride of the formula (II), and then reacting it with aqueous ammonia to obtain a 5-fluorobenzonitrile of the formula (III):
- ##STR4## wherein each of X.sub.1 and X.sub.3 is a halogen atom, and X.sub.2 is hydrogen or a halogen atom.
2-chloro-4,5-difluorobenzotrichloride of the formula:
- ##STR5##
2,4,5-trifluorobenzotrichloride of the formula:
- ##STR6##
2-bromo-4,5-difluorobenzotrichloride of the formula:
- ##STR7##
Dependencies are inferred from the claim text.