Process for preparing isoquinolines
AssigneeHoffmann-La Roche Inc.
InventorPhilippe Peter
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Abstract
A process for the preparation of isoquinolines of the formula ##STR1## wherein R is methyl or benzyl and R' is phenyl, p-hydroxyphenyl or p-methoxyphenyl, by reacting a solution of an enamine of the formula ##STR2## wherein R and R' are as described above, in a hydrocarbon with an anhydrous solution of p-toluenesulphonic acid in toluene or xylene at an elevated temperature.
Claims10
A process for preparing isoquinolines of the formula ##STR11## wherein R is methyl or benzyl and R' is phenyl, p-hydroxyphenyl or p-methoxyphenyl, which process comprises reacting a solution of an enamine of the formula ##STR12## wherein R and R' are as described above, in a hydrocarbon with an anhydrous solution of p-toluenesulphonic acid in toluene or xylene at an elevated temperature.
A process for the preparation of an enamine of the formula ##STR13## wherein R is methyl or benzyl and R' is phenyl, p-hydroxyphenyl or p-methoxyphenyl which process comprises reacting a solution of an amine of the formula ##STR14## wherein R is methyl or benzyl, in toluene or xylene while heating with a solution of an aldehyde of the formula R'CH.sub.2 CHO, wherein R' is phenyl, p-hydroxyphenyl or p-methoxyphenyl, in toluene or xylene.
A process for the preparation of an enamine of the formula ##STR15## wherein R is methyl or benzyl and R' is phenyl, p-hydroxyphenyl or p-methoxyphenyl which process comprises reacting a solution of an amine of the formula ##STR16## in a hydrocarbon, while heating with an ethereal solution of the aldehyde R'CH.sub.2 CHO.
Dependencies are inferred from the claim text.