Dibenzobicyclo(2.2.2) octane angiotensin II antagonists

A compound of formula I:

• ##STR128## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently --H, --COOH, --CONHOR.sup.14 ;
• --CONHNHSO.sub.2 CF.sub.3 ;
• --NHSO.sub.2 CF.sub.3 ;
• --CH.sub.2 NHSO.sub.2 CF.sub.3 ;
• ##STR129## alkyl of 1 to 5 carbon atoms;
• perfluoroalkyl of 1 to 5 carbon atoms;
• CN, --CO.sub.2 R.sup.15, phenyl;
• or where R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 are taken together to form an aliphatic ring of 3 to 6 carbon atoms;
• provided that at least one of R.sup.1, R.sup.2, R.sup.3, and R.sup.4 is always an acidic group defined by --COOH, --CONHOR.sup.14 ;
• --CONHNHSO.sub.2 CF.sub.3 ;
• --NHSO.sub.2 CF.sub.3 ;
• --CH.sub.2 NHSO.sub.2 CF.sub.3 ;
• ##STR130## and further provided that if Z, X and Y are not all N then at least one of R.sup.1 -R.sup.4 or R.sup.10 -R.sup.13 is always a tetrazolyl group as defined by ##STR131## R.sup.5 and R.sup.6 are independently H, CH.sub.3, Cl, Br, I, F, --OCH.sub.3, --OCOCH.sub.3 ;
• R.sup.7 is H, F, Cl, Br, I, NO.sub.2, perfluoroalkyl of 1 to 5 carbon atoms;
• CN;
• COR.sup.17 ;
• straight or branched alkyl of 1 to 6 carbon atoms;
• phenyl;
• phenylthio;
• alkenyl of 2 to 10 carbon atoms;
• alkynyl of 2 to 10 carbon atoms;
• phenylalkenyl where the alkenyl portion is 2 to 6 carbon atoms;
• phenylalkynyl where the alkynyl portion is 2 to 6 carbon atoms;
• heteroaryl selected from 2- and 3-thienyl, 2- and 3-furyl, and substituted phenyl, phenylalkenyl, phenylalkynyl, and heteroaryl selected from 2- and 3-thienyl, 2- and 3-furyl substituted with one or two substituents selected from halogen, alkoxy of 1 to 5 carbon atoms, alkyl of 1 to 5 carbon atoms, --NO.sub.2, --CN, --CF.sub.3, --COR.sup.15, --CH.sub.2 OR.sup.18, and --NHCOR.sup.18 where R.sup.18 is other than H;
• 1- or 2-naphthyl;
• 2-, 3-, 4-, 5-, 6-, or 7-benzofuryl, unsubstituted or substituted with one or two substituents selected from halogen, alkoxy of 1 to 5 carbon atoms, alkyl or 1 to 5 carbon atoms, --NO.sub.2, --CN, --CF.sub.3, --COR.sup.15, --CH.sub.2 OR.sup.18, and --NHCOR.sup.18 where R.sup.18 is other than H;
• R.sup.8 is H;
• CN;
• COR.sup.17 ;
• --(CH.sub.2).sub.n-1 CH(OR.sup.18)R.sup.19 ;
• --(CH.sub.2).sub.n O(CO)R.sup.18 where R.sup.18 is other than H;
• --(CH.sub.2).sub.n COR.sup.17 ;
• R.sup.9 is alkyl of 2 to 6 carbon atoms;
• alkenyl or alkynyl of 2 to 6 carbon atoms;
• cycloalkyl of 3 to 8 carbon atoms;
• cycloalkylalkyl of 4 to 8 carbon atoms;
• alkylthio where the alkyl portion is of 2 to 5 carbon atoms;
• R.sup.10, R.sup.11, R.sup.12, R.sup.13 are independently H, Cl, Br, I, F, NO.sub.2, CN, OH, alkyl of 1 to 4 carbon atoms;
• alkylcarbonyloxy of 1 to 4 carbon atoms;
• alkoxy of 1 to 4 carbon atoms;
• --CO.sub.2 H;
• --CO.sub.2 R.sup.15 ;
• --NHSO.sub.2 CF.sub.3 ;
• --CONHOR.sup.14 ;
• phenyl;
• ##STR132## R.sup.14 is H, methyl or benzyl;
• R.sup.15 is H;
• alkyl of 1 to 5 carbon atoms;
• branched alkyl of 1 to 5 carbon atoms;
• phenyl;
• R.sup.16 is CN, NO.sub.2 or CO.sub.2 R.sup.15 ;
• R.sup.17 is H, alkyl of 1 to 6 carbon atoms;
• --OR.sup.15, --NR.sup.18 R.sup.19 ;
• R.sup.18 and R.sup.19 are independently H, alkyl of 1 to 5 carbon atoms;
• phenyl;
• R.sup.20 and R.sup.21 are independently --H;
• Cl;
• Br;
• I;
• --SR.sup.15 ;
• --R.sup.17 ;
• --CN;
• --OR.sup.15 ;
• phenyl;
• substituted phenyl where the substituents are alkoxy of 1 to 5 carbon atoms, alkyl of 1 to 5 carbon atoms, fluorine;
• Z is N;
• CH;
• X is C-R.sup.7 ;
• C-R.sup.8 ;
• N;
• Y is C-R.sup.8 ;
• C-R.sup.7 ;
• N;
• X and Y are carbon atoms and Z is N when they are part of the following ring system;
• ##STR133## V is CH or N when W is CH;
• W is CH or N when V is CH;
• m is 1,2;
• n is 1-5.