Thiazole derivatives, their preparation and their use as fungicides

A method of combating a fungus at a locus, which comprises treating the locus with an effective amount of a fungicidal composition which comprises a carrier and as active ingredient an effective amount of a compound of formula I ##STR15## in which R represents a hydrogen atom or a group of formula --(CH.sub.2).sub.m --Y where m is 0 or 1 and Y represents an imidazolyl, triazolyl or pyridyl group optionally substituted by up to 3 substituents selected from halogen atoms, nitro, cyano, amino, mono- or di-(C.sub.1-4 alkyl)amino, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 haloalkyl groups and groups of the formula MR.sup.7 where M represents an oxygen or sulfur atom and R.sup.7 represents a hydrogen atom, C.sub.1-8 alkyl, C.sub.1-4 haloalkyl or phenyl group;

• R.sup.1 represents a group of formula --(CH.sub.2).sub.p --X or --N(Z)--CO--X where p is 0, 1 or 2, Z represents a hydrogen atom or a C.sub.1-10 alkyl group and X represents an N-linked piperidinyl, N-liked morpholino, N-linked imidazolyl or C-linked pyridyl group each optionally substituted by up to 3 substituents selected from halogen atoms, nitro, cyano, amino mono- or di-(.sub.1-4 alkyl)amino, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 haloalkyl groups, and groups of the formula MR.sup.7 as defined above, and, provided R represents a group in accordance with the formula --(CH.sub.2).sub.m --Y may additionally represent a hydrogen atom, a C.sub.1-10 alkyl or benzyl group each optionally substituted by one or more substituents selected from halogen atoms, phenyl, cyano, amino, nitro, mono- or di-(C.sub.1-4 alkyl)amino, C.sub. 1-4 haloalkyl groups and groups of the formula MR.sup.7 and C(O)MR.sup.7 where M and R.sup.7 are as defined above, or a phenyl group optionally substituted by up to 3 substituents selected from halogen atoms, nitro, cyano, amino, mono- or di-(C.sub.1-4 alkyl)amino, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 haloalkyl groups and groups of formula MR.sup.7 as defined above;
• n is 0 or 1;
• and R.sup.2 represents a phenyl group optionally substituted by up to 3 substituents selected from halogen atoms, phenyl, nitro, cyano, amino, mono- or di-(C.sub.1-4 alkyl)amino, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 haloalkyl groups and groups of formula MR.sup.7 as defined above;
• and acid addition salts, N-oxides, S-oxides and metal salt complexes thereof.

A method of combating a fungus at a locus, which comprises treating the locus with an effective amount of a compound of formula I ##STR16## in which R represents a hydrogen atom or a group of formula --(CH.sub.2).sub.m --Y where m is 0 or 1 and Y represents an imidazolyl, triazolyl or pyridyl group optionally substituted by up to 3 substituents selected from halogen atoms, nitro, cyano, amino, mono- or di-(C.sub.1-4 alkyl)amino, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 haloalkyl groups and groups of the formula MR.sup.7 where M represents an oxygen or sulphur atom and R.sup.7 represents a hydrogen atom, C.sub.1-8 alkyl, C.sub.1-4 haloalkyl or phenyl group;

• R.sup.1 represents a group of formula --(CH.sub.2).sub.p --X or --N(Z)--CO--X where p is 0, 1 or 2, Z represents a hydrogen atom or a C.sub.1-10 alkyl group and X represents an N-linked piperidinyl, N-linked morpholino, N-linked imidazolyl or C-linked pyridyl group each optionally substituted by up to 3 substituents selected from halogen atoms, nitro, cyano, amino mono- or di-(.sub.1-4 alkyl)amino, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 haloalkyl groups, and groups of formula MR.sup.7 as defined above, and, provided R represents a group in accordance with the formula --(CH.sub.2).sub.m --Y may additionally represent a hydrogen atom, a C.sub.1-10 alkyl or benzyl group each optionally substituted by one or more substituents selected from halogen atoms, phenyl, cyano, amino, nitro, or mono- or di-(C.sub.1-4 alkyl)amino, C.sub.1-4 haloalkyl groups and groups of the formula MR.sup.7 and C(O)MR.sup.7 where M and R.sup.7 are as defined above, or a phenyl group optionally substituted by up to 3 substituents selected from halogen atoms, nitro, cyano, amino, mono- or di-(C.sub.1-4 alkyl)amino, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 haloalkyl groups and groups of formula MR.sup.7 as defined above;
• n is 0 or 1;
• and R.sup.2 represents a phenyl group optionally substituted by up to 3 substituents selected from halogen atoms, phenyl, nitro, cyano, amino, mono- or di-(C.sub.1-4 alkyl)amino, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.1-4 haloalkyl groups and groups of formula MR.sup.7 as defined above;
• and acid addition salts, N-oxides, S-oxides and metal salt complexes thereof.