Quinolones, process for their preparation and pharmaceutical compositions containing same
AssigneeBouchara S.A.
InventorClaude Perrin
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AssigneeBouchara S.A.
InventorClaude Perrin
Estimating the term…
The invention concerns organic chemistry and, more precisely, therapeutic chemistry. It describes specifically novel 6-fluoro 7-piperdinyl quinolone-3 carboxylic acids having general formula (I) ##STR1## in which Z is an amino radical, and R1 is a radical (lower optionally hydroxylated alkyl), an acyl radical derived from a carboxylic organic acid, from an alkyl carbonic acid, or from an alkylsulfonic acid, or a carbonyl arylamino radical having formula (II) ##STR2## in which Ar is a mono or bicyclic aromatic radical, optionally substituted by one, two or three substituents selected form lower alkyls, halogens and trifluoromethyl; and X is oxygen or sulphur. The invention also concerns the addition salts of said acids. The compounds of general formula (I) constitute the active ingredients of antibacterial drugs.
A compound selected from the group consisting of a compound of the formula ##STR12## wherein Z is amino, R.sub.1 is selected from the group consisting of linear alkyl, hydroxy lower alkyl, acyl of an organic carboxylic acid, alkylcarbonic acid and alkyl sulfonic acid and ##STR13## Ar is a mono-or bicyclic aryl optionally substituted with 1 to 3 substituents selected from the group consisting of lower alkyl, halogen and --CF.sub.3, R.sub.2 is oxygen bound with a semi-polar valency and n is 0 or 1 and their non-toxic, pharmaceutically acceptable salts with a base or an acid when R.sub.1 is hydrogen, lower alkyl or hydroxy lower alkyl X is O or S.
Dependencies are inferred from the claim text.