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US 5,332,747 AGranted
Method for potentiating primary drugs in treating multidrug resistant parasitic disease cells
AssigneeCancer Biologics of America, Inc.
InventorKnox Van Dyke
Life of this patent
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Abstract
The specification discloses a method for enhancing the inhibiting action of drugs against multidrug resistant cells, representing various parasitic diseases, apparently by reversing the glycoprotein "pumps" associated with such cells.
Claims7
A method for potentiating a primary drug to treat cell multidrug resistance in Trypanosoma comprising:
- exposing multidrug resistant Trypanosoma cells to effective concentrations of a compound having the following formula:
- ##STR4## wherein R.sub.1 and R.sub.1 ' are the same or different short chained carbon based ligand;
- R.sub.2 is CH.sub.3 is and R.sub.3 is CH.sub.3 or hydrogen, and the isomeric configuration at the C-1' chiral carbon location is "S" and at least one of R.sub.2 and R.sub.3 comprises CH.sub.3.
Dependencies are inferred from the claim text.