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US 5,332,743 AGranted
Benzyl and benzhydryl alcohols
AssigneeMcNeilab, Inc.
InventorsEllen W. Baxter, Allen B. Reitz
Life of this patent
Estimating the term…
Abstract
Compounds of the general formula I: ##STR1## are disclosed as potent antipsychotic agents. Novel methods of use and intermediates used to make the compounds of formula I are also disclosed.
Claims20
A compound of the formula I:
- ##STR12## wherein R.sup.1 and R.sup.2 are independently selected from any of H, C.sub.1 -C.sub.8 alkyl, C.sub.4 -C.sub.10 cycloalkyl, C.sub.2 -C.sub.6 hydroxyalkyl, C.sub.1 -C.sub.8 alkoxyl, aryloxy, hydroxyl, trifluoromethyl, trifluoromethoxy, cyano, C.sub.1 -C.sub.8 alkythio, halogen, nitro, C.sub.1 -C.sub.8 haloalkyl, amino or C.sub.1 -C.sub.8 mono- or di-alkylamino, with the proviso that R.sup.1 and R.sup.2 can not both be H at the same time;
- variable n has a value of 1-4;
- A is N;
- R.sup.3 is selected from any of H, C.sub.1 -C.sub.8 acyl, C.sub.1 -C.sub.8 alkyl, C.sub.4 -C.sub.8 cycloalkyl or aralkyl wherein the alkyl portion is C.sub.1 -C.sub.8 ;
- R.sup.4 and R.sup.5 are independently selected from any of H, C.sub.1 -C.sub.8 alkyl, phenyl, substituted phenyl, aralkyl wherein the alkyl portion is C.sub.1 -C.sub.8, C.sub.4 -C.sub.8 cycloalkyl;
- wherein the phenyl is substituted with one or more of C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, halogen, trifluoromethyl, C.sub.1 -C.sub.8 alkylthio, dialkylamino (wherein each alkyl is C.sub.1 -C.sub.8), C.sub.1 -C.sub.8 alkylamino, nitro, or mono- or di-alkylamino sulfonyl (wherein each alkyl is C.sub.1 -C.sub.8);
- R.sup.9 and R.sup.10 are independently selected from any one of H, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, nitro, halogen, haloalkyl, C.sub.1 -C.sub.8 alkylthio, amino, or C.sub.1 -C.sub.8 mono- or di-alkylamino or a pharmaceutically acceptable salt thereof.
4 more elements
The compound of 2, wherein alkoxy is either i-propoxy or methoxy.
Dependencies are inferred from the claim text.