Renin inhibitors
AssigneeAbbott Laboratories
InventorSaul H. Rosenberg
Life of this patent
Estimating the term…
Abstract
A renin inhibiting compound of the formula: ##STR1## wherein R.sub.1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-l-oxo-4-piperazinyl, 2-oxo-4-piperazinyl, 4-morpholinyl, 4-thiomorpholinyl or 1-methyl-4-homopiperazinyl; R.sub.2 is benzyl, 2-phenylethyl, 1-naphthylmethyl or 2-naphthylmethyl; R.sub.3 is 4-thiazolyl, 2-amino-4-thiazolyl, 2-thiazolyl, 5-thiazolyl, 1-pyrazolyl, 3-pyrazolyl, 1-imidazolyl, n-propyl, isopropyl, CH.sub.3 S-- or CH.sub.3 SCH.sub.2 --; R.sub.4 is isobutyl or cyclopropyl; R.sub.5 is hydrogen or loweralkyl; and X is CH.sub.2 or NH; or a pharmaceutically acceptable salt, ester or prodrug thereof; with the proviso that when X is NH and R.sub.3 is 2-amino-4-thiazolyl, then R.sub.4 is cyclopropyl.
Claims6
A method for treating glaucoma or reducing and/or controlling intraocular pressure comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of the formula:
- ##STR9## or a pharmaceutically acceptable salt or ester thereof.
A method for treating glaucoma or reducing and/or controlling intraocular pressure comprising administering to a mammal in need of such treatment a therapeutically effective amount of the compound (2S)-2-Benzyl-3-(1-methyl-piperazin-4-ylsulfonyl)propionyl-(L)-(4-Thiazoly l)Ala Amide of (2S,3R,4S)-2-Amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane;
- or a pharmaceutically acceptable salt or ester thereof.
A topical ocular pharmaceutical composition for treating glaucoma or reducing and/or controlling intraocular pressure comprising an ophthalmologically acceptable pharmaceutical carrier and a therapeutically effective amount of a compound of the formula:
- ##STR10## or a pharmaceutically acceptable salt or ester thereof.
A topical ocular pharmaceutical composition for treating glaucoma or reducing and/or controlling intraocular pressure comprising an ophthalmologically acceptable pharmaceutical carrier and a therapeutically effective amount of the compound (2S)-2-Benzyl-3-(1-methyl-piperazin-4-ylsulfonyl)propionyl-(L)-(4-Thiazoly l)Ala Amide of (2S,3R,4S)-2-Amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane;
- or a pharmaceutically acceptable salt or ester thereof.
Dependencies are inferred from the claim text.