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US 5,332,736 AGranted
Anti-convulsant aroyl aminoacylpyrroles
AssigneeOrtho Pharmaceutical Corporation
InventorsRichard J. Carmosin, John R. Carson, Philip M. Pitis
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Abstract
Aroyl aminoacyl pyrroles are pharmaceutically useful as anti-convulsants, which includes utility for the treatment of epilepsy.
Claims11
A compound having anti-convulsant activity of the formula:
- ##STR56## wherein,
- A is simultaneously both ##STR57## n is an integer from 1 to 5;
- R.sup.1 is selected from the group consisting of H and C.sub.1-4 alkyl;
- R.sup.2 and R.sup.3 are selected from the group consisting of H and C.sub.1-4 alkyl;
- R.sup.4 and R.sup.5 are independently selected from the group consisting of H, C.sub.1-4 alkyl, phenyl C.sub.1-4 alkyl and substituted phenyl C.sub.1-4 alkyl where the substituent is on phenyl and selected from the group consisting of methyl and methoxy, or in the alternative, are fused and together with said nitrogen form a heterocyclic ring selected from the group consisting of:
- ##STR58## wherein Y is S or O, x is 3 to 7 and R.sup.7 is selected from the group consisting of methyl and hydroxymethyl;
- and
- R.sup.6 is selected from the group consisting of halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, hydroxy, nitro, amino, C.sub.1-4 acylamino, cyano, trihaloC.sub.1-4 alkyl, C.sub.1-4 alkylsulfonyl, C.sub.1-4 alkylsulfinyl, and C.sub.1-4 acyl,
- including pharmaceutically acceptable acid addition salts thereof.
6 more elements
Dependencies are inferred from the claim text.