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US 5,332,735 AGranted
Compounds of N-benzoylpyroline
AssigneeAdir et Compagnie
InventorsSylvain Rault, Marie P. Foloppe, Max Robba, Michel Boulouard, Pierre Renard, Michelle Devissaguet, Gerard Adam
Life of this patent
Estimating the term…
Abstract
Compounds of the general formula (I): ##STR1## where A, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are defined in the description. Medicinal products.
Claims23
A compound selected from those of formula (I):
- ##STR11## wherein A represents a CHOH,
- R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, which are identical or different, represent independently of one another a hydrogen, lower-alkyl, or hydroxyl, lower alkoxy group, or alternatively two adjacent groups selected from R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, namely R.sub.1 and R.sub.2, or R.sub.2 and R.sub.3 or R.sub.3 and R.sub.4 or R.sub.4, and R.sub.5 together form an --O--CH.sub.2 --O, --O--CH.sub.2 -- CH.sub.2 --O-- bridge, it being understood that:
- R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 cannot simultaneously represent hydrogen,
- R.sub.6 represents hydroxyl or lower alkoxy, amino, NR.sub.7 R.sub.8, or --O--B--NR.sub.7 R.sub.8 group with B representing lower alkyl and R.sub.7, R.sub.8, which are identical or different, represent hydrogen lower alkyl, cycloalkyl, cycloalkyl(lower alkyl), phenyl, lower phenylalkyl, substituted phenyl, or substituted lower phenylalkyl or R.sub.7 and R.sub.8 form with the nitrogen which carries them a monocyclic or bicyclic heterocyclic system, each ring comprising five or six atoms and optionally integrating in its skeleton one or two hetero atoms chosen from nitrogen, oxygen, and sulfur, and optionally substituted by lower alkyl, phenyl, lower phenylalkyl, substituted lower phenylalkyl, or substituted phenyl, the term substituted phenylalkyl, meaning that the aromatic nucleus of the group may be substituted by one or more lower alkyl, lower alkoxy, or trifluoromethyl groups,
- it being understood that cycloalkyl means a group with 3 to 8 carbon atoms inclusive and that lower alkyl means a linear or branched group with 1 to 6 carbon atoms inclusive,
- as well as, when appropriate, their isomers and their addition salts with a pharmaceutically, acceptable acid or base.
3 more elements
Dependencies are inferred from the claim text.