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US 5,332,669 AGranted
Prostate-derived mitogen
AssigneeThe Jewish Hospital of St. Louis
InventorThomas F. Deuel
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Abstract
A prostate-derived growth factor is disclosed which has a mol. wt. of about 28 kDa, an NH.sub.2 -terminal sequence substantially identical to the NH.sub.2 -terminal sequence of the 6 kDa mature rat EGF, potent mitogenic activity against NRK cells without additional carboxy terminal processing to the mature 6 kDa EGF molecular species, cross-reacts with antisera against rat EGF and its mitogenic activity is blocked by anti-EGF receptor antisera.
Claims2
A purified rat prostate tissue-derived growth factor having the following characteristics:
- (a) molecular weight of 25 kDa as determined by non-reduced sodium dodecylsulfate polyacrylamide gel electrophoresis,
- (b) an amino terminal sequence identical to the amino terminal sequence of FIG. 5A of the 6 kDa mature rat epidermal growth factor,
- (c) potent mitogenic activity against NRK cells without additional carboxy terminal processing to the mature 6 kDa epidermal growth factor species,
- (d) cross-reacts with antisera against rat epidermal growth factor, and
- (e) mitogenic activity is blocked by anti-epidermal growth factor receptor antisera.
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