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AssigneeAbbott Laboratories
InventorsMaciej Adamczyk, Jeffrey R. Fishpaugh, Donald Johnson, Robert E. Hruska
Estimating the term…
Immunoassay methods and reagents for the quantification of total doxepins (i.e., E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin) in a test sample are disclosed. The quantification of total doxepins is accomplished in an immunoassay employing antibodies and labeled reagents prepared with doxepin derivatives of the Formula II: ##STR1## wherein Y--Z can be C.dbd.CH or N--CH.sub.2, R.sub.` is a linking group, R.sub.2 can be H or CH.sub.3, and Q can be a detectable moiety or an immunogenic carrier material. The antibody reagent comprises antibodies which are capable of binding to total doxepins and which are produced with one or more immunogens prepared from the doxepin derivative of Formula II, and the labeled reagent is also prepared from the doxepin derivative of Formula II.
An immunoassay method for the quantification of total doxepins in a test sample, wherein said total doxepins comprise one or more of E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin, said method comprising the steps of:
A test kit for determining total doxepins in a test sample, said total doxepins comprising one or more of E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin, said test kit comprising:
Dependencies are inferred from the claim text.