Recombinant human rotavirus VP7 serotype 4
AssigneeThe University of Melbourne
InventorsMichael L. Dyall-Smith, Chris Hum, Ian H. Holmes, Michael A. Johnson, Peter R. Reeves
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Abstract
A human rotavirus gene encoding the major outer capsid glycoprotein (VP7) of the human rotavirus serotype 4 or a portion or sub-unit thereof. Expression vectors containing such a gene and expressing all or part of VP7 protein of human rotavirus serotype 4. Polyeptides corresponding to all or part of the VP7 protein of human rotavirus serotype 4 and vaccines containing such polypeptides.
Claims16
An isolated gene encoding a VP7 protein of human rotavirus serotype 4.
A fragment of an isolated gene encoding a portion of a VP7 polypeptide of human serotype 4, wherein said fragment selectively hybridizes with serotype 4 human rotaviral nucleic acids and detecting a hybridization product so formed.
A method for detecting the presence of serotype 4 human rotavirus in a sample which comprises hybridizing nucleic acids present in the sample with a labelled VP7 DNA or RNA probe which selectively hybridizes with serotype 4 human rotaviral nucleic acids and detecting a hydridization product so formed.
Dependencies are inferred from the claim text.