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US 5,332,576 AGranted
Compositions and methods for topical administration of pharmaceutically active agents
AssigneeNoven Pharmaceuticals, Inc.
InventorJuan A. Mantelle
Life of this patent
Estimating the term…
Abstract
A composition for topical application comprising a therapeutically effective amount of a pharmaceutical agent(s), a flexible, finite, pharmaceutically acceptable, bioadhesive carrier, and a solvent for the pharmaceutical agent(s) in the carrier and a method of administering the pharmaceutical agent to a mammal are disclosed.
Claims15
A method for administering one or more local anesthetic agents to a subject comprising the steps of:
- (a) providing a composition comprising a therapeutically effective amount of at least one local anesthetic;
- a pharmaceutically acceptable solvent for the anesthetic, in an amount from about 5 to about 70 weight percent based on the weight of the whole composition;
- and in admixture with the anesthetic agent in the solvent, a flexible, finite, pharmaceutically acceptable polysaccharide bioadhesive carrier in an amount from about 20 to about 50 weight percent based on the weight of the whole composition;
- wherein said composition is substantially free of water is substantially water insoluble and is a bioadhesive;
- and
- (b) contacting an area of skin or mucous membrane with the composition to administer the local anesthetics.
3 more elements
A method of administering one or more local anesthetic agents to a subject comprising the steps of:
- (a) providing a composition comprising a therapeutically effective amount of a first local anesthetic agent in base form;
- a therapeutically effective amount of a different, second local anesthetic agent in an acid-addition salt form;
- a pharmaceutically acceptable solvent for the anesthetic in an amount which ranges from about 5 to about 70 weight percent based on the weight of the whole composition;
- and in admixture with the anesthetic agent in the solvent, a flexible, finite, pharmaceutically acceptable bioadhesive carrier in an amount from about 20 to about 50 weight percent based on the weight of the whole composition;
- wherein said composition is substantially free of water and is substantially water insoluble;
- and
- (b) contacting an area of skin or mucous membrane with the composition to administer the local anesthetics.
4 more elements
Dependencies are inferred from the claim text.