Detection and treatment of infections with immunoconjugates
AssigneeImmunomedics, Inc.
InventorM. David Goldenberg
Life of this patent
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Abstract
A method of targeting a diagnostic or therapeutic agent to a focus of infection comprises injecting a patient infected with a pathogen parenterally with an antibody conjugate which specifically binds to an accessible epitope of the pathogen or of a pathogen-associated antigen accreted at the focus of infection, the antibody conjugate further comprising a bound diagnostic or therapeutic agent for detecting, imaging or treating the infection. Polyspecific composite conjugates enhance the efficacy of the method, which is especially useful for treating infections that are refractory towards systemic chemotherapy.
Claims29
A method of targeting a polyspecific diagnostic agent to a focus of infection, which comprises parenterally injecting a patient infected with a pathogen with an effective amount of a polyspecific diagnostic antibody conjugate comprising an immunoreactive composite of a plurality of chemically linked antibodies or antibody fragments which specifically bind to a plurality of epitopes on a single species of pathogen or an antigen shed by said pathogen or resulting from the fragmentation or destruction of said pathogen, wherein said conjugate further comprises at least one diagnostic agent.
A polyspecific diagnostic antibody conjugate for targeting a focus of infection, comprising an immunoreactive composite of a plurality of chemically linked antibodies or antibody fragments which specifically bind to a plurality of epitopes on a single species of pathogen or an antigen shed by said pathogen or resulting from the fragmentation or destruction of said pathogen, wherein said conjugate further comprises at least one diagnostic agent.
Dependencies are inferred from the claim text.