Purified active somatostatin receptor
AssigneeAmerican Cyanamid Company
InventorsCecil M. Eppler, John R. Zysk, Martin J. Corbett, Hong-Ming Shieh
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Abstract
The invention relates to a purified somatostatin receptor which is purified at least about 30,000-fold over the receptor which is membrane-bound. The invention also provides pharmaceutical compositions containing the receptor and antibodies to the receptor.
Claims5
A substantially pure somatostatin receptor, sufficiently free of associated proteins so as to be suitable for protein sequencing, which receptor is purified at least 30,000-fold relative to a whole cell non-solubilized membrane bound receptor and in glycosylated form as a molecular weight of between 75,000-90,000 daltons and consists of a 35,000-40,000 dalton core when not glycosylated.
Dependencies are inferred from the claim text.