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AssigneeThe Biomembrane Institute
InventorsSatoshi Kimura, Yasuyuki Igarashi, Sen-itiroh Hakomori, Mohammad N. Ahmad, Hirofumi Okoshi, Kazuko Handa
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The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors) and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, and modulating cell adhesion molecule expression and function using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.
A therapeutic method for moderating inflammatory reactions comprising administering to a host in need of treatment an amount of N,N,N-trimethylsphingosine, or a pharmaceutically acceptable salt thereof, capable of inhibiting neutrophil activity.
A therapeutic method for minimizing tissue damage resulting from superoxide exposure comprising administering to a host in need of treatment an amount of N,N,N-trimethylsphingosine, or a pharmaceutically acceptable salt thereof, capable of inhibiting neutrophil superoxide production.
A method for controlling neutrophil metabolism comprising exposing neutrophilis to an activity inhibiting amount of N,N,N-trimethylsphingosine.
A method of storing biologic material comprising exposing said material to a cell growth inhibiting amount of N,N,N-trimethylsphingosine.
Dependencies are inferred from the claim text.