1-phenylalkanecarboxylic acid derivatives as anticonvulsant and neuroprotective agents
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsAmy H. Newman, Silvia N. Calderon, Frank C. Tortella
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Abstract
The compounds belong to the class of non-narcotic, non-opiate derivatives the 1-phenylalkanecarboxylic acid basic structure useful as anticonvulsant and neuroprotective agents. The compounds include novel derivatives as well as previously published species. Methods for controlling convulsions in a variety of pharmaceutical formulations and modalities are also provided.
Claims17
A compound having the formula:
- wherein X is --CH.sub.2 O--, [--C(.dbd.O)O--, ] --C(.dbd.O)NH, CH.sub.2 NH, or --CH.sub.2 N(C.sub.2 H.sub.5), and n is an integer between 1-5;
- or a pharmaceutically acceptable salt thereof.
A method of treating a mammal for convulsions which comprises administering to said mammal an effective anticonvulsant or neuroprotective amount of a compound having the formula:
- ##STR4## wherein X is --CH.sub.2 O--, --C(.dbd.O)O--, --C(.dbd.O)NH, CH.sub.2 NH, or --CH.sub.2 N(C.sub.2 H.sub.5), and n is an integer between 1-5, provided that when X is --C(.dbd.O)O-- then n may not be 3;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.