Thioester enantiomeric compounds and their therapeutic uses
AssigneeSociete Civile Bioprojet
InventorsPierre Duhamel, Lucette Duhamel, Denis Danvy, Jean-Christophe Plaquevent, Bruno Giros, Claude Gros, Jean-Charles Schwartz, Jeanne-Marie Lecomte
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Abstract
The (R) or (S) isomer of acetorphan or N-/(acetylthiomethyl)-2-oxo-1-phenyl-3-propyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-3-benzyl-2-propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.
Claims5
In a method of treating a disease in which high blood pressure is reduced and diuresis and natriuresis are provoked, the improvement comprising both reducing high blood pressure and provoking diuresis and natriuresis by the administration to a patient of a therapeutically effective dose of a chiral compound selected from the group consisting of ##STR9##
Dependencies are inferred from the claim text.