.omega.-[2-(tetrazolylalkyl)cyclohexyl]-2-aminoalkanoic acids as antagonists of excitatory amino acid receptors
AssigneeGuilford Pharmaceuticals Inc.
InventorGregory S. Hamilton
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Abstract
The present invention pertains to antagonists of excitatory amino acid receptors, their method or preparation as well as compositions pertaining to them, which have the general formula: ##STR1## wherein R1 and R2 are selected from the group of hydrogen and C1 to C6 lower alkyl; the stereoisomers being in their resolved or racemic form; n and m are independently 0, 1, 2, or 3; and pharmaceutically acceptable salts thereof.
Claims14
An excitatory amino acid NMDA receptor antagonist having the general formula:
- ##STR7## wherein R1 and R2 are selected from the group consisting of hydrogen and C1 to C6 alkyl;
- the stereoisomers being in their resolved or racemic form;
- n and m are independently 0, 1, 2, or 3;
- and pharlnaceutically acceptable salts thereof.
A potent and selective excitatory amino acid NMDA receptor antagonist having the general formula:
- ##STR8## wherein R1 and R2 are selected from the group consisting of hydrogen and C1 to C6 alkyl;
- the stereochemical configuration of the compound specified as being of the (2R, 4R, 5S) configuration, and pharmaceutically acceptable salts thereof.
A method for antagonizing excitatory amino acid NMDA receptors by utilizing a compound having the general formula:
- ##STR9## wherein R1 and R2 are selected from the group consisting of hydrogen and C1 to C6 lower alkyl;
- the stereoisomers being in their resolved or racemic form;
- n and m are independently 0, 1, 2, or 3;
- and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.