Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen
AssigneeSepracor Inc.
InventorsJames W. Young, Nancy M. Gray, William J. Wechter
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Abstract
Methods and compositions are disclosed utilizing optically pure R(-) ketoprofen for the treatment of pain including, but not limited to, pain associated with toothaches, headaches, sprains, joint pain and post-surgical pain, for example dental pain and ophthalmic pain, while substantially reducing adverse effects including, but not limited to, gastrointestinal, renal and hepatic toxicities, and leukopenia, which are associated with the administration of racemic ketoprofen. Optically pure R(-) ketoprofen is also useful in treating pyrexia while substantially reducing the adverse effects associated with the administration of racemic ketoprofen.
Claims14
A method of eliciting an analgesic effect with reduced gastrointestinal toxicity in a human, comprising administering to said human a therapeutically effective analgesic amount of R(-) ketoprofen or a pharmaceutically acceptable salt thereof, substantially free of its S(+) stereoisomer.
The method of claim 3 wherein the amount of R(-) ketoprofen or a pharmaceutically acceptable salt thereof administered is from about 25 mg to about 2000 mg per day.
The method of claim 4 wherein the amount administered is from about 200 mg to about 1000 mg per day.
A method of treating pyrexia with reduced gastrointestinal toxicity in a human, comprising administering to said human a therapeutically effective antipyretic amount of R(-) ketoprofen or a pharmaceutically acceptable salt thereof, substantially free of its S(+) stereoisomer.
Dependencies are inferred from the claim text.