Thiazolidinedione derivatives as hypoglycemic agents

Abstract

Hypoglycemic thiazolidine-2,4-dione derivatives of the formula ##STR1## wherein the dotted line represents a bond or no bond; V is --CH.dbd.CH--, --N.dbd.CH--, --CH.dbd.N--, S, O or NR; W is S, SO, SO.sub.2, SO.sub.2 NR.sup.1, NR.sup.1 SO.sub.2, CONR.sup.1 or NR.sup.1 CO; X is S, O, NR.sup.2, --CH.dbd.N-- or --N.dbd.CH; Y is CH or N; Z is hydrogen, (C.sub.1 -C.sub.7)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, phenyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C.sub.1 -C.sub.3)alkyl, trifluoromethyl, (C.sub.1 -C.sub.3)alkoxy, fluoro, chloro or bromo; Z.sup.1 is hydrogen or (C.sub.1 -C.sub.3)alkyl; R, R.sup.1 and R.sup.2 are each independently hydrogen or (C.sub.1 -C.sub.4); and n is 1, 2 or 3; a pharmaceutically acceptable cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains a basic nitrogen.

Dependencies are inferred from the claim text.