1H-indazole-3-acetic acids as aldose reductase inhibitors

A compound of the formula ##STR11## wherein X.sup.1 and X.sup.2 are each independently hydrogen, fluoro, chloro, bromo, trifluoromethyl, (C.sub.1 -C.sub.3)alkyl or (C.sub.1 -C.sub.3)alkoxy;

• R is hydrogen or a radical group forming a conventional ester which is hydrolyzable under physiological conditions;
• R.sup.1 is ##STR12## Y is sulfur or oxygen;
• X.sup.3 and X.sup.4 are combined with the adjacent carbons to which they are attached to form a benzene ring substituted by X.sup.5 and X.sup.6 ;
• and
• X.sup.5 and X.sup.6 are each independently hydrogen, fluoro, chloro, bromo, trifluoromethyl, (C.sub.1 -C.sub.3)alkyl or (C.sub.1 -C.sub.3)alkoxy;
• and
• a pharmaceutically acceptable cationic salt thereof when R is hydrogen;
• or
• a pharmaceutically acceptable acid addition salt thereof.