Tetrahydropyridine isoxazoline derivatives

A compound selected from the following Formula I or Formula II

• wherein the dotted line represents the presence or absence of a double bond;
• wherein the isoxazole/isoxazoline ring is attached to either the 3- or 4-position of the tetrahydropyridine ring;
• wherein Ar is 2- or 3-thienyl, or phenyl substituted with from 1 to 3 substituents selected from chlorine, bromine, fluorine, trifluoromethyl, hydroxy, straight or branched alkoxy having from 1 to 4 carbon atoms, trifluoromethoxy, nitro, or NR.sub.3 R.sub.4 wherein each of R.sub.3 and R.sub.4 is hydrogen or alkyl having from 1 to 4 carbon atoms;
• wherein R.sub.1 is hydrogen, a straight or branched alkyl group having from 1 to 6 carbon atoms, a cycloalkylmethyl group wherein the cycloalkyl moiety has from 3 to 6 carbon atoms, phenyl(CH.sub.2).sub.n.sup.-- wherein n is one or two and the phenyl ring is unsubstituted, or is substituted with from 1 to 3 substituents selected from chlorine, bromine, fluorine, trifluoromethyl, hydroxy, straight or branched alkoxy having from 1 to 4 carbon atoms, straight or branched alkyl having from 1 to 4 carbon atoms, trifluoromethoxy, nitro, or --NR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are as defined above;
• and pharmaceutically acceptable salts thereof.