Substituted urea compounds and their preparation and use

Abstract

New substituted urea compounds of formula I, or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 is a group of formula II, III or IV ##STR2## where n is 2 or 3, p is 1 or 2, q is 1 to 3, r is 1-3 and R.sup.4 and R.sup.5 are H, C.sub.1-7 alkyl or C.sub.3-6 cycloalkyl; and wherein R.sup.2 is an oxadiazole, substituted with C.sub.1[ alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl, C.sub.3-7 cycloalkyl, benzyl, phenyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, amino or alkylamino; or wherein R.sup.2 --C--R.sup.6 .dbd.--N--O--R.sup.7 wherein R.sup.6 is hydrogen or methyl and R.sup.7 is C.sub.1-6 alkyl which may be substituted with C.sub.3-7 cycloalkyl; and wherein R.sup.3 is hydrogen, halogen, nitro, substituted amine, trifluoromethyl, C.sub.1-6 alkyl or C.sub.1-6 alkoxy. The compounds are useful in pharmaceutical preparations for treating psychotic disorders, nausea and vomiting.

Dependencies are inferred from the claim text.