Indole-7-carboxamide derivatives
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorGregory M. Shutske
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Abstract
This invention relates to indole-7-carboxamide derivatives of the formula ##STR1## where R.sub.1 through R.sub.6 are independently H, loweralkyl, aryl, and aralkyl; and in addition R.sub.3 and R.sub.5 can be joined together to form a piperazine ring of the formula ##STR2## where R.sub.7 is H, loweralkyl, aryl, arylloweralkyl, pyrimidyl; and R.sub.4 and R.sub.5 can be joined together to form a pyrrolidine ring of the formula ##STR3## where R.sub.8 is H, loweralkyl, aryl, arylloweralkyl; X is H, loweralkyl, halogen, NO.sub.2, CF.sub.3, NH.sub.2, and OR.sub.9 ; where R.sub.9 is loweralkyl, arylloweralkyl and n is an integer of 1 to 3; and the pharmaceutically acceptable acid addition salts thereof and the optical isomers thereof where such isomers exist.
Claims45
A compound of the formula ##STR21## where R.sub.1 and R.sub.2 are independently H, loweralkyl and arylloweralkyl;
- wherein R.sub.3 through R.sub.6 are independently selected from aryl, arylloweralkyl, and in addition R.sub.3 and R.sub.5 can be joined together to form a piperazine ring of the formula ##STR22## where R.sub.7 is H, loweralkyl, aryl, arylloweralkyl, pyrimidyl;
- and R.sub.4 and R.sub.5 can be joined together to form a pyrrolidine ring of the formula ##STR23## where R.sub.8 is H, loweralkyl, aryl, arylloweralkyl;
- X is H, loweralkyl, halogen, NO.sub.2, NH.sub.2, CF.sub.3 and OR.sub.9 where R.sub.9 is loweralkyl, arylloweralkyl and n is an integer of 1 to 3;
- and the pharmaceutically acceptable acid addition salts thereof and the optical isomers thereof where such isomers exist.
An analgesic composition which comprises an effective pain alleviating amount of a compound of the formula ##STR24## where R.sub.1 and R.sub.2 are independently H, loweralkyl and arylloweralkyl;
- wherein R.sub.3 through R.sub.6 are independently selected from aryl, arylloweralkyl, and in addition R.sub.3 and R.sub.5 can be joined together to form a piperazine ring of the formula ##STR25## where R.sub.7 is H, loweralkyl, aryl, arylloweralkyl, pyrimidyl;
- and R.sub.4 and R.sub.5 can be joined together to form a pyrrolidine ring of the formula ##STR26## where R.sub.8 is H, loweralkyl, aryl, arylloweralkyl;
- X is H, loweralkyl, halogen, NO.sub.2, NH.sub.2, CF.sub.3 and OR.sub.9 where R.sub.9 is loweralkyl, arylloweralkyl and n is an integer of 1 to 3:
- and the pharmaceutically acceptable acid addition salts thereof and the optical isomers there where such isomers exist;
- and a suitable carrier therefor.
A method of alleviating of pain in a mammal which comprises administering to a mammal a pain alleviating effective amount of a compound of the formula ##STR27## where R.sub.1 and R.sub.2 are independently H, loweralkyl, aryl, and arylloweralkyl;
- wherein R.sub.3 through R.sub.6 are independently selected from aryl, arylloweralkyl, and in addition R.sub.3 and R.sub.5 can be joined together to form a piperazine ring of the formula ##STR28## where R.sub.7 is H, loweralkyl, aryl, arylloweralkyl, pyrimidyl;
- and R.sub.4 and R.sub.5 can be joined together to form a pyrrolidine ring of the formula ##STR29## where R.sub.8 is H, loweralkyl, arylloweralkyl;
- X is H, loweralkyl, halogen, NO.sub.2, CF.sub.3 and OR.sub.9, where R.sub.9 is loweralkyl, arylloweralkyl;
- and n is an integer of 1 to 3;
- and the pharmaceutically acceptable salts thereof and the optical isomers thereof where such isomers exist.
Dependencies are inferred from the claim text.