Di-N-acetyl lysoganglioside compositions
AssigneeThe Wellcome Foundation Limited
InventorsEzio Tubaro, Giovanni Cavallo
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Abstract
The invention relates to N-deacetyl-lysogangliosides and physiologically acceptable salts thereof, especially those of formula (I): ##STR1## wherein R represents --CH.dbd.CH(CH.sub.2)nCH.sub.3 or --CH.sub.2 CH.sub.2 (CH.sub.2)nCH.sub.3 ; n is 12 or 14; R.sup.1 represents ##STR2## or hydrogen; and R.sup.2 represents hydrogen or acetyl; for use in therapy. The compounds are useful as inhibitors of phospholipases A.sub.2, and of superoxide production, as antiproliferative and immunosuppressant agents and in the treatment of autoimmune diseases. The invention also relates to the use of N-deacetyl-lysogangliosides for the manufacture of medicaments for the treatment of the aforementioned conditions.
Claims2
A pharmaceutical composition comprising an N-deacetyl-lysoganglioside of the formula:
- ##STR8## wherein R represents --CH.dbd.CH(CH.sub.2)nCH.sub.3 or --CH.sub.2 CH.sub.2 (CH.sub.2)nCH.sub.3 ;
- n is 12 or 14;
- R.sup.1 represents ##STR9## and R.sup.2 represents hydrogen or acetyl;
- or a physiologically acceptable salt thereof
- together with a pharmaceutically acceptable carrier therefor.
Dependencies are inferred from the claim text.