Method of impeding apoptosis of CD4 cells in persons infected with human immunodeficiency virus
AssigneeAbbott Laboratories
InventorFrederick O. Cope
Life of this patent
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Abstract
The apoptosis of CD4 cells in a person infected with the human immunodeficiency virus may be impeded by enterally feeding to the infected person a nutritional product which contains soy protein hydrolysate having a degree of hydrolysis in the range of about 14 to 17 and a molecular weight partition, as determined by size exclusion chromatography, wherein 30%-60% of the particles have a molecular weight in the range of 1500-5000 Daltons. The nutritional product also contains a source of intact protein. The nutritional product has a ratio, by weight, of n-6 to n-3 fatty acids of about 1.3:1 to 2.5:1. The nutritional product also contains a source of dietary fiber.
Claims16
A method of impeding the apoptosis of CD4 cells in a person infected with human immunodeficiency virus comprising enterally feeding to said person a therapeutically effective amount of an enteral nutritional product comprising:
- (a) a soy protein hydrolysate having a degree of hydrolysis in the range of about 14 to 17 and a molecular weight partition, as determined by size exclusion chromatography wherein 30%-60% of the particles have a molecular weight in the range of 1500-5000 Daltons and the amino acid profile of the soy protein hydrolysate has less than 1% free amino acids;
- (b) a second source of protein which comprises a source of intact protein in a quantity sufficient to yield a stable emulsification of the soy protein hydrolysate and the intact protein in the nutritional product;
- and
- (c) a source of fat characterized by the ratio, by weight, of the sum of the n-6 fatty acids to the sum of the n-3 fatty acids being in the range of about 1.3:1 to 2.5:1.
Dependencies are inferred from the claim text.