Back to results
US 5,330,915 AGranted
Pressure control system for a bioreactor
AssigneesEndotronics, Inc., Tecnomara Deutschland GmbH
InventorsJohn R. Wilson, Ewald Kowol
Life of this patent
Estimating the term…
Abstract
A pressure control system for a bioreactor of the type having a gas space and a cell culture space therein is supplied with a gas such as oxygen separately from the supply of liquid nutrient media. The pressures in the gas space and the pressure in the cell culture space are controlled so that a higher pressure is maintained in the cell culture space than in the gas space to prevent displacement of the liquid nutrient media.
Claims6
A pressure control system for a bioreactor comprising:
- a bioreactor having a gas space and a cell culture space therein separated by a hydrophobic gas permeable membrane which is impermeable to cells and liquids;
- gas supply means and gas removal means connected to a gas inlet and a gas outlet, respectively, of said gas space in said bioreactor;
- liquid nutrient media supply means and liquid waste removal means connected to said bioreactor separately from said gas supply means and gas removal means;
- and
- gas pressure control means for controlling the gas pressure in said gas space and liquid nutrient media pressure control means for controlling pressure in said cell culture space being operatively connected to said bioreactor to maintain a higher pressure in said cell culture space than in said gas space to prevent displacement of the liquid media in the cell culture space.
2 more elements
Dependencies are inferred from the claim text.