Apolipoprotein B-specific monoclonal antibodies produced by two novel hybridomas
AssigneeThe Scripps Research Institute
InventorsSteven Young, Joseph L. Witztum, Linda K Curtiss
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Abstract
Two hybridomas that produce receptors containing antibody combining sites that immunoreact with apolipoprotein B-100 are disclosed as are uses for the receptors, compositions and diagnostic systems that include the receptors.
Claims6
A hybridoma having the ATCC accession number HB 8746.
An antibody that (a) immunoreacts with apoprotein B-100, and (b) has an antibody combining site secreted by the hybridoma having the ATCC accession number HB 8746.
A cell culture comprising:
- (a) the hybridoma having ATCC accession number HB 8746;
- (b) antibody molecules secreted by said hybridoma that immunoreact with apoprotein B-100;
- and
- (c) a culture medium for said hybridoma.
The culture of claim 19 wherein said antibody is in substantially pure form.
A sterile affinity sorbant comprised of biologically active antibody molecules that immunoreact with apoprotein B-100 and are secreted by hybridoma HB 8746, wherein said antibody molecules are affixed to a solid matrix to form a solid support.
Dependencies are inferred from the claim text.