Monoclonal antibodies to an autocrine growth factor antigen that binds to activated lymphocytes and cancer cells
OwnerRonald J. Billinginventor
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Abstract
A monoclonal antibody recognizing an autocrine growth factor that reacts with activated lymphocytes and cancer cells is described. The growth factor, a small glycoprotein is distinct from interleukin 2 and other known growth factors by function, structure and tissue distribution. A homologous growth factor is present in lymphoid tissues of a wide range of vertebrate species. Diagnostic and therapeutic uses of the growth factor and antibody-growth factor complex are disclosed. Also disclosed are therapeutic uses of synthetic analogues and peptide derivatives of the antigen.
Claims3
A partially purified antigen of vertebrate source that has the following properties:
- (a) it functions as an autocrine growth factor produced by tumor cells and activated lymphocytes,
- (b) it binds to the surface membrane of tumor cells and stimulates the growth of these cells and cells of the lymphoid series,
- (c) it is present on the cell membrane and within the cytoplasm of tumor cells and activated lymphocytes,
- (d) it is present in the cytoplasm of unstimulated normal peripheral blood lymphocytes but when these cells are stimulated by antigens or by mitogens, said antigen appears also on the cell membrane,
- (e) it is present on lymphocytes activated in vitro by mitogens,
- (f) it is present in the medium from growing cancer cells and in the serum of patients with cancer and diseases in which activated lymphocytes are present,
- (g) its molecular weight is approximately 15,000 daltons,
- (h) is capable of binding to CBL1 monoclonal antibody which is produced by the hybridoma cell line having the ATCC number HB8214.
Dependencies are inferred from the claim text.