Methods of preparing bulk delivery matrices by solid-state dissolution
AssigneeJanssen Pharmaceutica NV
InventorsDilip J. Gole, R. Saul Levinson, James Carbone, J. Desmond Davies
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Abstract
A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the solidified matrix with a second solvent that is substantially miscible with the first solvent at a temperature lower than the solidification point of the first solvent, the matrix components being substantially insoluble in the second solvent, whereby the first solvent is substantially removed resulting in a usable matrix.
Claims15
A method for preparing a porous delivery matrix comprising the steps of:
- (a) solidifying a dispersion or solution of a matrix forming agent in a first solvent;
- (b) contacting the solidified dispersion or solution with a second solvent, the first solvent in the solidified dispersion or solution being substantially miscible with the second solvent, the solidification point of the first solvent being higher than the solidification point of the second solvent, the second solvent being at a temperature at or higher than the solidification point of the second solvent and at a temperature at or lower than the solidification point of the first solvent, the matrix forming agent being substantially insoluble in the second solvent, the contacting being sufficient to substantially remove the first solvent from the solidifed disperison or solution thereby yielding a delivery matrix that is substantially free of the solvent;
- and
- (c) recovering the delivery matrix.
A method for preparing a porous foam dosage form comprising the steps of:
- (a) forming a dispersion of a gas and a matrix forming agent in a first solvent;
- (b) maintaining the gas in a dispersed state within said dispersion;
- (c) solidifying the dispersion;
- (d) contacting the solidified dispersion with a second solvent, the first solvent in the solidified dispersion being substantially miscible with the second solvent, the solidification point of the first solvent being higher than the solidification point of the second solvent, the second solvent being at a temperature at or higher than the solidification point of the second solvent and at a temperature at or lower than the solidification point of the first solvent, the matrix forming agent being substantially insoluble in the second solvent, the contacting being sufficient to substantially remove the first solvent from the solidified dispersion thereby yielding a foam dosage form;
- and
- (e) recovering the foam dosage form.
Dependencies are inferred from the claim text.