Delivery matrices prepared by solid-state dissolution
AssigneeJanssen Pharmaceutica NV
InventorsDilip J. Gole, R. Saul Levinson, James Carbone, J. Desmond Davies
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Abstract
A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the solidified matrix with a second solvent that is substantially miscible with the first solvent at a temperature lower than the solidification point of the first solvent, the matrix components being substantially insoluble in the second solvent, whereby the first solvent is substantially removed resulting in a usable matrix.
Claims13
A porous unit dosage form prepared according to a method comprising the steps of:
- (a) dispersing or dissolving a matrix forming agent in a first solvent;
- (b) solidifying a unit volume of the dispersion or solution;
- and
- (c) contacting the solidified unit volume with a second solvent, the first solvent in the solidified unit volume being substantially miscible with the second solvent, the solidification point of the first solvent being higher than the solidification point of the second solvent, the second solvent being at a temperature at or higher than the solidification point of the second solvent and at a temperature at or lower than the solidification point of the first solvent, the matrix forming agent being substantially insoluble in the second solvent, the contacting being sufficient to substantially remove the first solvent from the solidified unit volume yielding a unit dosage form;
- and
- (d) recovering the unit dosage form.
Dependencies are inferred from the claim text.