A process for preparation of Concentrated Fluid Symphytum Extracts, CFSE, which comprises the steps of:
- selecting live, healthy plants of single or mixed wild or non-wild taxonomically-classified plant species comprising
- S. officinale, S. asperum, S. armeniacum, S. tauricum, S. sylvaticum, S. peregrinum, S. anatolicum, S. icaricum, S. orientale, S. kurdicum, S. pseudobutbosum, S. uplandicum, S. circinale, S. ottomanum, S. icaricum, S. brachycalyx, S. aintabicum, S. longisetum, S. bornmuelleri, S. tuberosum, S. bulbosum, S. ibericum, or S. longipetiolatum ;
- harvesting whole parts of said plant species comprising one or more of roots, stems, leaves, anthers, buds, and blooms;
- charging said whole harvested parts immediately into protective, tightly-closed chambers, which are sunlight-opaque, and which provides a protective environment to prevent moisture evaporation and light-activated chemical, biological processes;
- removing said charged whole parts from said protective chamber and comminuting them immediately within a protective environment to a length or thickness dimension of approx. 1 mm;
- charging said comminuted parts within a time period of approximately 1-2 hours into a closed, extraction apparatus adapted to provide controlled ranges of internal pressure, temperature and a forced-convection-contact-velocity differential between said comminuted parts and an extraction fluid for an extended diffusion time,
- charging an extraction fluid into said extraction apparatus wherein said extraction fluid is a chemical compound, a single phase or multiple phases, a vapor or liquid solution, or a suspension, and the mass ratio of said extraction fluid to said comminuted plant parts lies in the range 0,01 to 10000 wherein said extraction fluid comprises single-or two-phase water, single- or two-phase water solutions with one or more biocompatible solutes, two-phase fluids with a liquid with equilibrium vapor phase, multi-phase, multi-component biocompatible fluid solutions with one or more dispersed liquid phases, and an equilibrium vapor phase, or multi-phase, multi-component biocompatible fluid solutions with one or more dispersed liquid phases, and an equilibrium vapor phase containing dispersed droplets, particles, or vesicles;
- extracting, by diffusional transfer, biologically active species into said extraction fluid from said comminuted plant parts in said extraction apparatus for a total diffusion time in the range 1-200 hours while forced-convection-contact-velocity differential is maintained within the range 0,5-3 meter/sec;
- and internal temperature is in the range 20-380 deg. K. and an absolute internal pressure is in the range 1-5000 kPa;
- separating solid plant residues from supernatant Concentrated Fluid Symphytum Extract by physical means comprising solvent extraction, sedimentation, coagulation, distillation, centrifugation or filtration through microporous, adsorbent media,
- wherein said extraction fluid consists of 1,2 propanediol-free liquid or vapor phases.